912 STUDIES RELATED TO THE CRISIS EPISODES IN SICKLE CELL PATIENTS

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The Effect of L-Glutamine on Pain Crisis Reduction in Patients with Sickle Cell Anemia and Sickle β°-Thalassemia

Background: A low level of L-glutamine, a precursor of nicotinamide adenine dinucleotide (NAD) in red blood cells (RBCs), is identified as an underlying mechanism for the potential decrement of the NAD redox and the incidence of pain crisis in sickle cell anemia (SCA). The aim of this study is to assess the impact of oral L-glutamine therapy on pain crisis reduction in patients with SCA and sic...

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Studies of peripheral circulation during sickle-cell crisis.

IT IS WELL recognized that patients with sickle-cell disease may have a low saturation and tension of arterial blood oxygen. Although arterial anioxemia was first observed in 1942, its exact mechanism is still unknown.1 It has been shown that the hemoglobin dissociation curve of these patients is shifted to the right, probably because of a decrease in erythrocyte pH.2, 3 Therefore, a norimal le...

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Sickle cell crisis and pregnancy.

Pregnant women with sickle cell disease appear to be more likely to experience antepartum, intrapartum, and postpartum complications when compared with unaffected women. Access to high-risk obstetric care, patient education, and close follow-up is important to minimize maternal morbidity and mortality. A high index of suspicion and good diagnostic acumen is necessary to obtain optimal results i...

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Munchausen sickle cell painful crisis.

A 22-year-old female with factitious sickle cell anemia and recurrent painful crises is described. Because she had sickle cell trait and iron deficiency anemia, she could successfully feign the symptoms of homozygous sickle cell anemia. The identification of this syndrome in patients with genetic disorders is presented.

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Paclitaxel-induced sickle cell crisis.

PURPOSE A case of paclitaxel-induced painful crisis in a patient with breast cancer and hemoglobin sickle cell disease (SCD) is reported. SUMMARY A 55-year-old postmenopausal African-American woman had stage IIB invasive ductal carcinoma of the left breast. She was not taking any medications and did not report a history of cancer or other diseases. She had mild microcytic anemia, but the rest...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1985

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-198504000-00942